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Noteskarts Pharmacology Sample Paper

Pharmacology-2Try attempt all Questions:Long Answers (Answer 6 out of 7) = 6 x 5 = 30.1.. Define any two hormones and their physiological role in the body.

• Thyroid hormones.
• Progesterone.
• Oxytocin.

2.. Write various route of drug administration and their advantages.3.. Classify the general anaesthesia and write the pharmacological actions on CNS.4.. Define any two with suitable example

• Diuretics.
• Laxative.
• Sedative.

5.. Define any two with suitable example.

• Cholinergic drugs
• Local anaesthetic agent.
• Adrenergic drugs.

6.. Define any two with suitable example.

• Anti-malarial agents
• NSAIDs
• Anti-hypertensive drugs.

7.. Discuss the steps of drug absorption and factors which promote or enhance the drug absorption. Short Answers (Answer 10 out of 11) = 10 x 3 = 30.1. Write the short notes on general mechanism of drug action.2. Discuss the bioavailability.3. Define the term miotics and mydriatics with examples.4. Discuss the physiological role of histamine in the body.5. Write the physiological and pathological role of any two hormone

• Insulin.
• Thyroid hormones.
• Oxytocin.

6. Write the short notes on drug metabolism and their excretion.7. Write the branches of pharmacology and their scope.8. Classify the neuromuscular blocking agents.9. Write short notes on biologicals.10. Write detail about any two chemotherapeutic agents.

• Penicillin’s.
• Aminoglycosides.
• Sulphonamides.

11. Write short notes on opioid analgesics. Objective type Answers (Answer all 20).1. Which of the following drugs is classified as a mydriatic?a) Pilocarpineb) Atropinec) Timolold) Latanoprost 2. Which of the following drugs is classified as a miotic?a) Brimonidineb) Dorzolamidec) Timolold) Pilocarpine 3. What is the dose-limiting side effect of miotics?a) Hypertensionb) Bradycardiac) Hyperglycemiad) Respiratory depression 4.What is the pharmacological action of anti-anginal drugs?a) Increase myocardial oxygen supplyb) Decrease myocardial oxygen demandc) Increase heart rated) Decrease blood pressure 5. Which of the following is an indication for the use of mydriatics?a) Narrow-angle glaucomab) Chronic open-angle glaucomac) Posterior uveitisd) Acute angle-closure glaucoma 6. What is the pharmacological action of anti-platelet agents?a) Reduce blood pressureb) Prevent blood clot formationc) Increase blood flowd) Reduce inflammation 7. Which of the following drugs is a calcium channel blocker used to treat hypertension and angina?a) Atenololb) Metoprololc) Verapamild) Lisinopril 8. What is the mechanism of action of anti-hypertensive drugs?a) Increase blood pressureb) Decrease blood pressurec) Increase heart rated) Decrease heart rate 9. What is the pharmacological action of thrombolytic drugs?a) Increase blood clot formationb) Decrease blood clot formationc) Break down blood clotsd) Inhibit platelet aggregation 10. What is the mechanism of action of anti-tussive agents?a) They reduce inflammation in the airwaysb) They thin the mucus in the airwaysc) They relax the smooth muscles in the airwaysd) They suppress the cough reflex 11. Morphine affects the eyes by:a)Producing miosis through an action on the oculomotor nerveb) Producing mydriasis through an action on the sympathetic systemc) Decreasing pupillary responses to lightd) Directly acting on the smooth muscle of the iris 12. Spironolactone is a prodrug and its active metabolite isa) Desmethyl spironolactoneb) Canrenonec) Acetylspironolactoned) None of the above 13. Acetylcholine and physostigmine are examples of……………… type drug interaction.a) Synergismb) Additionc) Potentiationd) Antagonism 14. In the bioassay the conviction activity in mice is observed during……………use.a) Insulinb) Histaminec) Prolactind) Oxytocin 15. ………………drug having highest volume of distribution.a) Warfarinb) Amitriptylinec) Digoxind) Alcohol 16. Isolated rabbit jejunum is useda) To check adrenergic activity and mechanismb) To check the activity of skeletal musclec) To check the activity straight muscled) None of the above 17. Bioassays are carried out to:a) Measure the pharmacological activity of a drugb) Avoid clinical trials for new drugsc) Detect the impurity in a given drugd) Screen from pharmacogenetic influences of new drugs 18. Most common Phase -2nd reaction isa) Sulfate conjunction:b) Glucuronide conjugationc) α amino acid conjunctiond) Methylation 19. Drug having high affinity but low intrinsic activity is calleda) Partial agonist b) Antagonist c) Non-competitive antagonism d) Competitive antagonism 20. In urinary incontinence following drug is widely used:a) Pirenzepineb) Cyclopentolatec) Darifenacind) Hyoscine