Pharmacology & Toxicology MCQs For DPEE | D.Pharma Exit Exam Most Important Question 2022-23 Noteskarts

Pharmacology & Toxicology Class Test | Pharmacology & Toxicology DPEE Test

This test is Improve for Pharmacy exam like Diploma in Pharmacy exit exam MCQs (DPEE), GPAT, & other competitive exam. Pharmacology & Toxicology Class Test | Pharmacology & Toxicology DPEE Test

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Pharmacology & Toxicology MCQs for DPEE | D.Pharma Exit Exam Most Important Question 2022-23

1 / 50

Which of the following receptor shows the slowest response?

Ion channel

GPCR

Enzyme linked

Steroid receptor

2 / 50

………………drug having highest volume of distribution.

Amitriptyline

Digoxin

Warfarin

Alcohol

3 / 50

Isolated rabbit jejunum is used

To check the activity of skeletal muscle

To check the activity straight muscle

To check adrenergic activity and mechanism

None of the above

4 / 50

Sweating is inhibited by

All of the above

Phenothiazines

Scopolamines

Atropine

5 / 50

Atropine over Dosage may cause all of the following except

Relaxation of GIT smooth muscle

Increased heart rate

Mental aberration

Miosis

6 / 50

Muscarinic receptor M4 are mainly located at

Exocrine gland

Corpus striatum

Cerebral cortex

Heart

7 / 50

Epinephrine is added to local anaesthetics

To stimulate would healing

To prolong the action of local anaesthetics

To cause haemeostasis

All of the above

8 / 50

Which of the following drug may cause cycloplegia when used topically in the eye?

Pilocarpine

Bethanechol

Physostigmine

Atropine

9 / 50

Darifenacin is a

M2 antagonist

M3 agonist

M1 antagonist

M3 antagonist

10 / 50

In the treatment of myasthenia gravis, the best agent for distinguishing between myashenic crisis and cholinergic crisis, given intravenously is

Neostigmine

Physostigmine

Pyridostigmine

Edrophonium

11 / 50

Drug having high affinity but low intrinsic activity is called

Competitive antagonism

Non-competitive antagonism

Antagonist

Partial agonist

12 / 50

Which of the following a is directly acting sympathomimetic agent?

Amphetamine

All of the above

Ephedrine

Dopamine

13 / 50

Hormones that increase cyclic AMP in the larger organ include all except

F S H

Prolactin

Vasopressin

14 / 50

Pilocarpine is classified as

Cholinomimetic

Cholinesterase inhibitor

Cholinolytics

Sympathomimetic

15 / 50

All of the following may enhance the action of sulfonylureas except

Ethanol

Prednisolone

Salicylates

Clofibrate

16 / 50

Neostigmine may cause all of the following except

Bronchoconstriction

Constipation

Reversible inhibition of acetyl cholinesterase

Block accommodation reflex

17 / 50

Drug of choice in the treatment of cardiogenic shock is

Dopamine

Epinephrine

Isopropanol

All of the above

18 / 50

Most serious adverse effect of antithyroid drug, propylthiouracil is

Nephritis

Alopecia

Agranulocytosis

Drug fever

19 / 50

Which of the following agent irreversibly bound with acetyl cholinesterase.

Ecothiopate

Physostigmine

Both a and b

Dispropyl flurophosphate

20 / 50

Most of the drug is absorbed through

Facilitated diffusion

Ion pair transport

Passive diffusion

Active transport

21 / 50

Undesirable effects of oral contraceptives include all except

Hypertension

Breast Carcinoma

Dysmenorrhoea

Cerebral thrombosis

22 / 50

Ganglionic blocking agent may cause all of the following except

Inhibit erection and ejaculation

Reduced sweating

Loss of accommodation

Mydriasis

23 / 50

Drug of the following drugs. Does not cross the blood-brain barrier?

Atropine

Neostigmine

Physostigmine

All of the above

24 / 50

Beta agonist used in bronchial asthma exert action by

Blocking B2 receptor

Stimulating B2 receptor

Blocking B1 receptor

Stimulating B1 receptor

25 / 50

In the bioassay the conviction activity in mice is observed during……………use.

Prolactin

Insulin

Oxytocin

Histamine

26 / 50

Serious unwanted effect of epinephrine is

Respiratory difficulty

Palpitation

Tremor

Cerebral heamorrhage

27 / 50

Antidote of organo phosphorus poisoning is

Tubocurarine

Physostigmine

Neostigmine

Pralidoxime

28 / 50

Bioassays are carried out to:

Screen from pharmacogenetic influences of new drugs

Measure the pharmacological activity of a drug

Avoid clinical trials for new drugs

Detect the impurity in a given drug

29 / 50

Neostigmine effectively antagonizes skeletal muscle relaxation produced by

Pancuronium

Tubocurarine

All of the above

Gallamine

30 / 50

Following are the chloride channel blocker
(P) Amiloride (Q) Cadmium
(R) Picrotoxin. (S) Ketamine

R and S

Q and S

Q and R

P and S

31 / 50

Most common Phase -2nd reaction is

Methylation

Glucuronide conjugation

Sulfate conjunction:

α amino acid conjunction

32 / 50

Spironolactone is a prodrug and its active metabolite is

Canrenone

Desmethyl spironolactone

None of the above

Acetylspironolactone

33 / 50

Atropine blocks the muscarinic actions of acetylcholine by

Inhibiting release from storage sites

All of the above

Inhibiting synthesis of ACH

Competing at receptor sites

34 / 50

Alcuronium is a semisynthetic derivative with similar properties of

Succinylcholine

Hexamethonium

D-tubocurarine

Gallamine

35 / 50

Activation of alpha-2 receptors in the pancreatic islets causes

Suppression of insulin secretion

Suppression of glucagon secretion

None of above

Stimulation of insulin release

36 / 50

Drug of choice in motion sickness is

Metoclopramide

Atropine

Scopolamine

Carbamazepine

37 / 50

Morphine affects the eyes by:

Producing mydriasis through an action on the sympathetic system

Directly acting on the smooth muscle of the iris

Producing miosis through an action on the oculomotor nerve

Decreasing pupillary responses to light

38 / 50

All of the following statement related to neostigmine are correct except

Neostigmine is medium duration of action

Neostigmine has indirect effect on neuromuscular junctions

All of the above

Neostigmine is a quaternary ammonium compound

39 / 50

Tolbutamide is contraindicated in

Pregnancy

All of the above

IDDM

Renal insufficiency

40 / 50

Which of the following is CYP450 enzyme inhibitor?

Carbamazepine

Rifampicin

Barbiturates

Grape juice

41 / 50

Action of D-tubocurarine is

Competitive blockade of muscarinic receptors

None of above

Irreversible blockade of muscarinic receptor

Competitive blockade of nicotinic receptors

42 / 50

Mechanism of action of organic phosphate parathion is

Phosphorylation of the esteratic site of cholinesterase

Acetylation of the esteratic site of cholinesterase

Phosphorylation of the cationic site of cholinesterase

Acetylation of the cationic site of cholinesterase

43 / 50

Local anesthetics produce:

Blocking pain sensation without loss of consciousness

A stupor or somnolent state

Analgesia, amnesia, loss of consciousness

Alleviation of anxiety and pain with an altered level of consciousness

44 / 50

Major adverse effect of clonidine is

Tachycardia

Dry mouth

Hypertension

Bradycardia

45 / 50

Phentolamine is competitive antagonism of

Noradrenaline

Atropine

Acetylcholine

Isoprenaline

46 / 50

In urinary incontinence following drug is widely used:

Darifenacin

Hyoscine

Pirenzepine

Cyclopentolate

47 / 50

In belladonna poisoning convulsions can be controlled by

Carbamazepine

Diazepam

Paraldehyde

Phenytoin

48 / 50

Atropine is used prior the administration of a general Anesthetics agent due to become it

Prevents miosis

Inhibits salivation and secretion of respiratory tract

Cause skeletal muscle relaxation

Inhibits GIT motility

49 / 50

Acetylcholine and physostigmine are examples of……………… type drug interaction.

Antagonism

Addition

Potentiation

Synergism

50 / 50

Antidote of atropine is

None of the above

Physostigmine

Pralidoxime

Neostigmine

Your score is

The average score is 29%

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