It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 h and Vd of 5 L. The dose required in a sustained release product will be

Amitryptyline is synthesized from the following starting material:

An isosteric replacement for carboxylic acid group is

The common structural feature amongst the three
categories of anti-convulsant drugs barbiturates,
succinimides and hydantoins is
(a)  (b)
(c)  (d)

Which one of the following drugs does not act through G-Protein coupled receptors?

Selective serotonin reuptake inhibitor is

In nail polish, the following polymer is used as a film-former:

The given antibiotic is an example of ansamycins:

Guggul lipids are obtained from

Rabies vaccine (living) is prepared using

The ability of human eye using illuminated area to detect a particle is limited to

Oxidative phosphorylation involves

One mg of Lycopodium spores used in quantitative microscopy contains an average of

For glyburide, all of the following metabolic reactions are logical except:

In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than

Quassia wood is adulterated with

Ganciclovir is mainly used for the treatment of infection caused by

The volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be

Select the correct combination of drugs for the treatment of patients suffering from Hepatitis C.

Choose the right combination:

Nicotinic action of acetylcholine is blocked by the drug

Improvement of memory in Alzheimer’s disease is brought about by drugs which increase transmission in

What quantities of 95% v/v and 45% v/v alcohols are to be mixed to make 800 mL of 65% v/v alcohol?

Streptomycin cannot be given orally for treatment of tuberculosis because

Indicate the HPLC detector that is most sensitive to change in temperature:

Aminotransferases usually requires the following for their activity:

In the mixing of thymol and menthol, the following type of incompatibility occurs:

X-ray crystallographic analysis of an optically active compound determines its

Aliskiren acts by

Purity of water can be assessed by determining one of its following properties instrumentally:

Glass transition temperature is detected through
(a)
(b)
(c)
(d)

The role of borax in cold creams is

Thioglycolic acid-like compounds have applications in following type of cosmetic formulations:

In which of the following techniques, the sample is kept below triple point?

The amount of barbaloin present in Aloe vera is

Identify the one rational combination which has clinical benefit:

Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system:

Anisocytic stomata are present in

Coulter counter is used in determination of

In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than

In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their

Which one of the following is not an ex-officio member of Pharmacy Council of India?

Geriatric population should be included in the following phase of clinical trials:

In thiazides, following substituent is essential for diuretic activity:

One of the following statements is not true:

Myasthenia gravis is diagnosed with improved neuromuscular function by using

The healing agent used in hand creams is

An example of N-glycoside is

Which of the following non-opioid analgesics is a prodrug?

Measurement of inulin renal clearance is a measure for

In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is

Identify the drug which is not used in the treatment of malaria caused by Plasmodium falciparum.

Which filler can not be used for the preparation of tablets for amine containing basic drugs to avoid discolouration of the tablets?

Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products?

How many mL of a 1:500 w/v stock solution should be used to make 5 litres of 1:2000 w/v solution?

Chemical nomenclature of procaine is
(a)
(b)
(c)
(d)

In the TCA cycle, at which of the following enzyme-catalysed steps, incorporation of elements of water into an intermediate of the cycle takes place?

The applicability of Noyes-Whitney equation is to describe

Highly branched three dimensional macromolecules with controlled structures with all bonds originating from a central core are known as

Which one of the following is used as a mood stabilizer for bipolar disorder and also in certain epileptic
convulsions?

Which one of the following drugs is withdrawn from the market due to torsade de pointes?

A compound will be sensitive towards IR radiation only when one of the following properties undergo
transition on

Ethambutol molecule has

Alkaloids are not precipitated by

Which one of the following drugs is not a typical antipsychotic agent?

Which one of the following statements is wrong?

Class 100 area is referred to

Cardiac glycosides have the following configuration in the Aglycone part of the steroid nucleus:

Bloom strength is used to check the quality of
(a) (b)
(c)  (d)

Many xenobiotics are oxidized by cytochrome P450 in order to

Sildenafil is used for treatment of one of the following
disorders:

Cyclophosphamide as anticancer agent acts as

The following protein/polypeptide has a quaternary structure:

Barbiturates with substitution at the following position possess acceptable hypnotic activity:

Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with chronic myeloid Leukemia?

Which one of the following is a plasminogen activator?

Tropane alkaloids are not present in

The rate limiting step in cholesterol biosynthesis is one of the following:

Drugs following one compartment open model pharmacokinetics eliminate

Which of the following monoclonal antibodies is prescribed for patients with non-Hodgkin’s Lymphoma?

A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram h/mL, respectively. The absolute availability of the drug through oral administration is

The chemical behaviour of morphine alkaloid is

Drugs in suspensions and semi-solid formulations always degrade by

Bacopa monnieri plant belongs to the family

Artemisinin contains the following group in its structure:

Which one of the following drugs is most effective in preventing transmission of HIV virus from the mother to the foetus?

Digitalis toxicity is enhanced by co-administration of

The characteristic of non-linear pharmacokinetics includes:

Stevens Johnson syndrome is the most common adverse effect associated with one of the following category of drugs:

Gingkgo biloba is used for its

Humectants added in cosmetic preparations generally act by

The temperature condition for storage of drug products under cold temperature is given as

Which one of the following drugs specifically inhibits calcineurin in the activated T lymphocytes?

At physiological pH, the following compound would be mostly in the

The effects observed following systemic administration of levodopa in the treatment of Parkinsonism have been
attributed to its catabolism to dopamine. Carbidopa can markedly increase the proportion of levodopa that
crosses the blood-brain barrier by

A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is

Triterpenoids are active constituents of

Which one of the following statements is wrong?

Eugenol is present in

Which one of the following is a flocculating agent for a negatively charged drug?