Biostatistics and Research Methodology PDF Notes | B Pharmacy 8th Semester Noteskarts
Syllabus
Unit: 1
- Introduction: Statistics, Biostatistics, Frequency distribution
- Measures of central tendency: Mean, Median, Mode- Pharmaceutical examples
- Measures of dispersion: Dispersion, Range, standard deviation, Pharmaceutical problems
Correlation: Definition, Karl Pearson’s coefficient of correlation, Multiple correlation – Pharmaceuticals examples
Unit: 2
- Regression: Curve fitting by the method of least squares, fitting the lines y= a + bx and x = a + by, Multiple regression, standard error of regression – Pharmaceutical Examples
- Probability: Definition of probability, Binomial distribution, Normal distribution, Poisson’s distribution, properties – problems Sample, Population, large sample, small sample, Null hypothesis, alternative hypothesis, sampling, essence of sampling, types of sampling, Error-I type, Error-II type, Standard error of mean (SEM) – Pharmaceutical examples
- Parametric test: t-test(Sample, Pooled or Unpaired and Paired) , ANOVA, (One way and Two way), Least Significance difference
Unit: 3
- Non Parametric tests: Wilcoxon Rank Sum Test, Mann-Whitney U test, Kruskal-Wallis test, Friedman Test
- Introduction to Research: Need for research, Need for design of Experiments, Experiential Design Technique, plagiarism
- Graphs: Histogram, Pie Chart, Cubic Graph, response surface plot, Counter Plot graph
- Designing the methodology: Sample size determination and Power of a study, Report writing and presentation of data, Protocol, Cohorts studies, Observational studies, Experimental studies, Designing clinical trial, various phases.
Unit: 4
- Blocking and confounding system for Two-level factorials
- Regression modeling: Hypothesis testing in Simple and Multiple regressionmodels
- Introduction to Practical components of Industrial and Clinical Trials Problems: Statistical Analysis Using Excel, SPSS, MINITAB®, DESIGN OF EXPERIMENTS, R – Online Statistical Software’s to Industrial and Clinical trial approach
Unit: 5
- Design and Analysis of experiments:
- Factorial Design: Definition, 2², 2³ design. Advantage of factorial design
- Response Surface methodology: Central composite design, Historical design, Optimization Techniques