Pharmaceutical Organic Chemistry-3 PDF Notes | B Pharmacy 4th Semester Noteskarts

Unit: 1

Stereo isomerism

Optical isomerism –

  • Optical activity, enantiomerism, diastereoisomerism, meso compounds
  • Elements of symmetry, chiral and achiral molecules
  • DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
  • Reactions of chiral molecules
  • Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute
Unit: 2

Geometrical isomerism

  • Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
  • Methods of determination of configuration of geometrical isomers.
  • Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
  • Stereospecific and stereoselective reactions
Unit: 3

Heterocyclic compounds:

  • Nomenclature and classification
  • Synthesis, reactions and medicinal uses of following compounds/derivatives
  • Pyrrole, Furan, and Thiophene
  • Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
Unit: 4
  • Synthesis, reactions and medicinal uses of following compounds/derivatives
  • Pyrazole, Imidazole, Oxazole and Thiazole.
  • Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
  • Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
Unit: 5

Reactions of synthetic importance

  • Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
  • Oppenauer-oxidation and Dakin reaction.
  • Beckmanns rearrangement and Schmidt rearrangement.
  • Claisen-Schmidt condensation