Pharmaceutical Organic Chemistry-3 PDF Notes | B Pharmacy 4th Semester Noteskarts
Syllabus
Unit: 1
Stereo isomerism
Optical isomerism –
- Optical activity, enantiomerism, diastereoisomerism, meso compounds
- Elements of symmetry, chiral and achiral molecules
- DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
- Reactions of chiral molecules
- Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute
Unit: 2
Geometrical isomerism
- Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
- Methods of determination of configuration of geometrical isomers.
- Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
- Stereospecific and stereoselective reactions
Unit: 3
Heterocyclic compounds:
- Nomenclature and classification
- Synthesis, reactions and medicinal uses of following compounds/derivatives
- Pyrrole, Furan, and Thiophene
- Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
Unit: 4
- Synthesis, reactions and medicinal uses of following compounds/derivatives
- Pyrazole, Imidazole, Oxazole and Thiazole.
- Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
- Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
Unit: 5
Reactions of synthetic importance
- Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
- Oppenauer-oxidation and Dakin reaction.
- Beckmanns rearrangement and Schmidt rearrangement.
- Claisen-Schmidt condensation