Medicinal Chemistry-II PDF Notes | B Pharmacy 5th Semester Noteskarts
Syllabus
Unit: 1
Antihistaminic agents: Histamine, receptors and their distribution in the humanbody
- H1-antagonists: Diphenhydramine hydrochloride\*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride\*, Phenidamine tartarate, Promethazine hydrochloride\*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium
- H2-antagonists: Cimetidine\*, Famotidine, Ranitidin.
- Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole
Anti-neoplastic agents
- Alkylating agents: Meclorethamine\*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa
- Antimetabolites: Mercaptopurine\*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate\*, Azathioprine
- Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin
- Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate
- Miscellaneous: Cisplatin, Mitotane.
Unit: 2
Anti-anginal
- Vasodilators: Amyl nitrite, Nitroglycerin\*, Pentaerythritol tetranitrate, Isosorbide dinitrite\*, Dipyridamole.
- Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
Diuretics
- Carbonic anhydrase inhibitors: Acetazolamide\*, Methazolamide, Dichlorphenamide.
- Thiazides: Chlorthiazide\*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide,
- Loop diuretics: Furosemide\*, Bumetanide, Ethacrynic acid.
- Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride.
- Osmotic Diuretics: Mannitol
Anti-hypertensive Agents
- Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.
Unit: 3
- Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate\*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.
- Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol
- Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin\*, Anisindione, clopidogrel
- Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan.
Unit: 4
Drugs acting on Endocrine system
- Nomenclature, Stereochemistry and metabolism of steroids
- Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol.
- Drugs for erectile dysfunction: Sildenafil, Tadalafil.
- Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol
- Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone
- Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazol
Unit: 5
Antidiabetic agents: Insulin and its preparations
- Sulfonyl ureas: Tolbutamide\*, Chlorpropamide, Glipizide, Glimepiride.
- Biguanides: Metformin.
- Thiazolidinediones: Pioglitazone, Rosiglitazone
- Meglitinides: Repaglinide, Nateglinide.
- Glucosidase inhibitors:Acrabose, Voglibose.
Local Anesthetics: SAR of Local anesthetics
- Benzoic Acid derivatives: Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine.
- Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine.
- Miscellaneous: Phenacaine, Diperodon, Dibucaine.*